What is Anophthalmia


  • Anophthalmia is a medical term used to characterize {the} absence of {the} globe and ocular tissue from {the} orbit. 
  • This was initially reported more than 400 years ago, yet it is only recently that cogent reconstructive options became available.
  • There are various explanations why one might lose an eye.
  • Surgeries which result in anophthalmos




T2-weighted MR scan of a patient with unilateral anophthalmia.

MRI orbital MRI anophthalmosis


Note {the} presence of amorphous tissue and structures resembling extraocular muscles within {the} anophthalmic right orbit. The right optic nerve/chiasm junction appears attenuated rather than absent suggesting possible residual optic nerve neural tissue

There are three classifications for this condition:

  • Primary anophthalmia is a complete absence of eye tissue due to a failure of {the} part of {the} brain that forms {the} eye.
  • Secondary anophthalmia {the} eye starts to develop and for some reason stops, leaving {the} infant with only residual eye tissue or extremely small eyes which can only be seen under close examination.
  • Degenerative anophthalmia {the} eye started to form and, for some reason, degenerated. One reason for this occurring could be a lack of blood supply to {the} eye.


  1. Anophthalmia ( A medical term used to characterize {the} absence of {the} globe and ocular tissue from {the} orbit ) can be congenital (present at birth) or acquired later in life. Congenital anophthalmia can occur alone or along with other birth defects. Cases of Anophthalmia might result from inherited genetic mutations, sporadic genetic mutations, chromosome abnormalities, prenatal environmental insult or unknown. 
  2. True or primary anophthalmos is very rare. Only when there is complete absence of {the} ocular tissue within {the} orbit can {the} diagnosis of true anophthalmos be made. Extreme microphthalmos is seen more commonly. In this condition, a very small globe is present within {the} orbital soft tissue, which is not visible on initial examination.
  3. Anophthalmia and microphthalmia might occur secondary to {the} arrest of development of {the} eye at various stages of growth of {the} optic vesicle. It is important to recognize microphthalmia because {the} development of {the} orbital region, as well as {the} lids and fornices, is dependent on {the} presence of a normal-sized eye in utero. Anophthalmia is frequently a clinical characteristic of Trisomy 13 which is a Gross Chromosomal Abnormality.

     (Anophthalmia is very rare but {the} exact incidence is unknown. One report from a prospective study of 50,000 newborns found an incidence of microphthalmia of 0.22 per 1,000 live births)
  • trauma
  • infection
  • tumor (such as retinoblastoma, choroidal malignant melanoma)
  • advanced ocular disease (corneal disease, advanced resistant glaucoma)

Demographics & Movie




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