Lacrimal System

Overview, Signs and Symptoms of an Obstruction

  • The lacrimal gland produces tears which enter into {the} "duct"
    that drain {the} tears from {the} eye into {the} nose. The most common symptoms are
    If one has a plugged up "tear duct," not only will tears spill over {the} eyelids and
    n down {the} face, but {the} stagnant tears within {the} system can become infected.
    • (1) excess tearing (tears could run down {the} face) and
    • (2) mucous discharge
  • This could lead to recurrent red eyes and infections.
  • The excessive tearing can also produce secondary skin changes on {the} lower eyelids.Site of  congenital NLDO

Congenital Nasolacrimal Duct Obstruction

The nasolacrimal duct is a duct that connects {the} lacrimal glands in {the} eye to {the} nasal cavity. In this article, we shall briefly review {the} epidemiology, clinical presentation and {the} common causes of this condition.


  • Clinical research has shown that nasolacrimal duct obstruction occurs in 2 to 4 out of 100 newborn babies. However, this number dramatically increases in children who have Down syndrome with statistics suggesting about 22% to 36% developing this condition.
  • There are a number of different reasons why nasolacrimal duct obstruction occurs. The epidemiological statistics have shown that of all {the} cases, 35% of them actually due to obstruction, 15% occur due to {the} improper formation of {the} opening of {the} lacrimal duct (punctual agenesis), 10% have some form of abnormal connection i.e. congenital fistula and 5% have defects in {the} structure of {the} head and face.
  • As such, congenital nasolacrimal duct obstruction does not differentiate between race and sex. It is typically seen in newborns.
  • Congenital nasolacrimal duct obstruction can result in numerous clinical presentations. These conditions bring with them a varying degree of morbidity and mortality.
  • The initially condition that could occur is amniotocoele. Here, there is distension of {the} tear producing gland i.e. {the} lacrimal gland. Amniotic fluid enters {the} lacrimal sac and gets trapped within it. This can result in swelling of {the} lacrimal sac. Treating this can be done through inserting a small probe through {the} nasolacrimal duct.
  • Dacrocystitis is another condition that could develop where there is inflammation and distension of {the} lacrimal sac. It occurs in {the} neonatal period which is just after {the} baby has been born. In these patients as well, probing {the} lacrimal sac through {the} nasolacrimal duct is {the} treatment.
  • Finally, in newborns who have narrowing of {the} nasolacrimal duct, accumulation of pus or pus within {the} lacrimal sac could take place. This can manifest as constant watering of {the} eye or expulsion of pus from {the} eye. The treatment usually involves antibiotics, compression and massage of {the} lacrimal sac. If left untreated, newborns could have matted eyes every morning and excessive tearing of {the} eyes.


Blockage simple obstruction
congenital fistula (as seen to {the} left)
acute dacryocystitis
congenital dacryocele or mucocele

Clinical presentation

  • History forms an important part of making a diagnosis. There could be a family history of nasolacrimal duct problems and other abnormalities such as glaucoma. A detailed examination of {the} eye is useful in determining whether {the} patient has congenital nasolacrimal duct disease.
  • A special test known as {the} dye disappearance test is useful in determining whether there is any obstruction. In addition, tests to ascertain whether {the} patient has glaucoma need to be conducted.


Nasolacrimal duct obstruction is not very common but does have some recognised causes. The top three causes include –

  • genetic causes i.e. having a family history of nasolacrimal duct obstruction
  • premature birth
  • drug use by {the} mother during pregnancy

It is commonly accompanied by other eye abnormalities.



  • 9 out of 10 cases resolve within {the} initially year of life. If required, massage therapy over {the} lacrimal gland could be helpful.
  • In patients in whom this does not work, using a probe can cure up to 95% of cases. Other procedures include {the} insertion of a tube into {the} nasolacrimal gland or {the} insertion of a balloon catheter.
  • Special surgical procedures include a dacrocystorhinostomy - a procedure that helps restore normal tear flow.


Acquired (ADULT-ONSET) Nasolacrimal Duct Obstruction

Epiphora is {the} overflow of tears which is caused by an imbalance in tear production and tear drainage. Other than conditions that cause an abnormal increase in tear production, an abnormality in tear drainage is {the} most likely cause of epiphora. It could be either functional due to a displaced punctum, eyelid laxity, weak orbicularis, or facial nerve palsy or an anatomical obstruction could block {the} drainage of tears. Anatomical obstruction of {the} nasolacrimal duct could be congenital which occurs during {the} neonatal period or acquired which manifests during adulthood.

Classification of Acquired Nasolacrimal Drainage Obstruction (NLDO)

Acquired nasolacrimal drainage obstruction could be primary or secondary.

  • Primary acquired nasolacrimal drainage obstruction (PANDO) is caused by inflammation or fibrosis without any precipitating cause. The name was given by Linberg and McCormick in 1986.
  • Secondary acquired lacrimal drainage obstruction (SALDO) is further classified further based on aetiology as infectious, inflammatory, neoplastic, traumatic and mechanical. This classification was proposed by Bartley.


  • Although quite common, {the} frequency of nasolacrimal drainage obstruction is unknown. It has no racial predilection.
  • PANDO is more commonly seen in middle-aged and elderly females. This is due to {the} significantly smaller dimensions in {the} lower nasolacrimal fossa and middle nasolacrimal duct among women. Middle-aged women exhibit alterations in {the} dimensions of {the} bony nasolacrimal canal that coincides with osteoporotic changes elsewhere in {the} body, which supports {the} higher incidence of PANDO in women. Some suggest that sudden hormonal changes incite generalized de-epithelialization predisposing a narrow duct to be blocked by sloughed off debris.
  • SALDO is aetiologically classified as infectious, inflammatory, neoplastic, traumatic, and mechanical.
  • Infectious lacrimal drainage obstruction: Bacteria, viruses, fungi, and parasites that have all been implicated are as follows:
  1. Bacterial Causes – Most common causes are Actinomyces, Propionibacterium, Fusobacterium, Bacteroides, Mycobacterium, and Chlamydia.
  2. Viral Causes – Most commonly Herpes virus. Due to canalicular obstruction and damage.
  3. Fungal Causes - Aspergillus, Candida, Pityrosporum, and Trichophyton. Usually cause obstruction due to dacryolith/stone or cast formation.
  4. Parasitic Causes – Rare but can be caused by Ascaris lumbricoides entering through {the} valve of Hasner.

Inflammatory lacrimal drainage obstruction: May be endogenous or exogenous in origin.

  • Endogenous Causes – Most commonly due to Wegener granulomatosis and sarcoidosis. Other causes include cicatricial pemphigoid, sinus histiocytosis, Kawasaki disease, and scleroderma.
  • Exogenous Causes – Eye drops, radiation, systemic chemotherapy, and bone marrow transplantation all cause punctal and canalicular scarring, stenosis and occlusion in varying degrees.

Neoplastic lacrimal drainage obstruction: Neoplasms cause obstruction by primary growth, secondary spread, or metastatic spread.

Traumatic lacrimal drainage obstruction: May be iatrogenic or non-iatrogenic.

  • atrogenic Causes - Trauma and subsequent scarring due to overenthusiastic lacrimal probing, orbital decompression surgery, paranasal, nasal, and craniofacial surgery all cause obstruction.
  • Non-iatrogenic Causes - Either blunt or sharp injury to {the} canaliculus, lacrimal sac, and nasolacrimal duct results in post-traumatic dacryostenosis.

Mechanical lacrimal drainage obstruction

  • Intraluminal foreign bodies – Dacryoliths or casts due to infection or long-term use of topical medications.
  • External compression – Due to rhinoliths, nasal foreign bodies, or mucoceles. Dentigerous cyst in {the} maxillary sinus is also thought of as a culprit.


  • Patients with NLDO most commonly present with epiphora, mucoid or purulent discharge with a painful, swollen medical canthus. They commonly have features of recurrent dacryocystitis, recurrent conjunctivitis, or ocular pemphigus. Some cases present with bloody tears and even epistaxis as in nasal, sinus or lacrimal sac tumours.
  • A thorough past ocular and medical history is in order to evaluate {the} cause of {the} disease. Always ask for previous eye surgery, lid surgery, use of antiglaucoma medications, or any other topical medications. Past medical history should all causes cited in {the} previous section.

On examination, {the} following findings could be present.

  • Gross observation shows overflowing tears, fluctuant tender mass over medial canthus, mucoid or purulent eye discharge. Regurgitation test results in mucoid reflux with lacrimal massage indicating lower system obstruction.
  • Slit lamp examination shows enhancement of tear meniscus height by fluorescein greater than 2 mm, punctal stenosis, canaliculitis, concretions expressed from {the} punctum


  • Laboratory studies include sending lacrimal discharge for Gram/Giemsa stain, culture and sensitivity, KOH and anticytoplasmic antibodies.
  • Imaging studies could include dacryocystography, dacryoscintigraphy, CT scan, CT dacryocystography (CTDCG), nasal endoscopy, or Gadolinium-enhanced magnetic resonance dacryocystography.
  • Other tests include Schirmer test, Fluorescein dye disappearance test, lacrimal irrigation, probing of {the} canaliculi, Jones dye tests, microreflux test, Hornblass saccharine test
  • Diagnostic canalicular irrigation determines {the} level of canalicular obstruction staging it as partial obstruction, total common canalicular obstruction, total functional occlusion and complete nasolacrimal obstruction.


Medical Care

  • Topical antibiotics in early infections
  • Systemic antibiotics in chronic or severe infections

Surgical Care

  • External dacryocystorhinostomy
  • Endoscopic mechanical/nonlaser dacryocystorhinostomy
  • Endoscopic laser dacryocystorhinostomy
  • Endoscopic laser-assisted dacryocystorhinostomy
  • Conjunctivodacryocystorhinostomy (CDCR)
  • Balloon catheter dilatation
  • Inferior meatus surgery



wpe14.jpg (26191 bytes)wpe13.jpg (33766 bytes) The photo and CT on {the} left represents a nasolacrimal duct tumor which can result in a nasolacrimal duct obstruction.

Once {the} tumor was removed, silicone intubation performed, {the} patient's symptoms of tearing resolved


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